RESET ECSA Bonner Biotech Brand
Client Education Document
Conventional & Alternative Medicine
Guidance Series
Volume 03 · Client Questions & Answers

Topical Support through the Skin

Answers to questions Clients ask most about CBD, hemp, the endocannabinoid system, and how to use Reset ECS Topical Products.

Author Barry Bonner  ·  Issued by Reset ECS
BON-FAQ · 060726-v01
Orientation

In Brief

  • The endocannabinoid system (ECS) is the body’s own balancing network. Modern life can leave it running low.
  • These products come from hemp, not marijuana. They contain no detectable THC and will not get you high.
  • This is not plain CBD. A broad spectrum of eleven hemp compounds works together to support the ECS.
  • Made from natural ingredients with no synthetic additives. The oil is vegan; the salve contains natural beeswax.
The Questions

Client Questions & Answers

01

What is this, exactly?

It is a natural hemp product. It brings together a broad spectrum of the hemp plant’s beneficial compounds in a base of natural oils. Your body has its own balancing network, the endocannabinoid system, and these plant compounds are ones it already recognises, so they help support it.

02

I’ve never heard of the endocannabinoid system. What is it?

It is one of the body’s main balancing systems. It runs through your nervous system, immune system, gut and skin, and its job is to keep everything steady. Your body even makes its own cannabinoids. In many of us that system is not running at its best, and the hemp compounds in this help supplement it.

03

Why might my endocannabinoid system be running low?

Modern life tends to work against it. The body builds its own cannabinoids largely from omega-3 fats, yet most modern diets are heavy in omega-6, from processed foods and industrial seed oils, and short on omega-3. That leaves the system short on raw material.

Ongoing stress, poor sleep, too little movement, alcohol and simply getting older can all lower it further. As whole, varied foods give way to processed and heavily modified ingredients, diets drift further from the balance the system depends on. When it runs low, plant compounds from hemp can help supplement it.

04

Is there anything else I can do to support it?

Yes, quite a lot. The same habits that keep the rest of you healthy also feed the ECS: more omega-3 (oily fish, walnuts, flax and the like) and fewer processed foods, regular movement, good sleep, and keeping stress in check. Whole-plant hemp is one more way to support the system alongside these basics, not a replacement for them.

05

Is this the same as marijuana?

No. This comes from hemp, marijuana’s sister plant. Marijuana is grown for THC, the part that makes people feel high. Hemp is grown for the supportive compounds. There is nothing in this that gets you high.

06

Will it get me high or affect my head?

No. The part of the plant that makes people high is THC, and this is made to contain no meaningful THC, so it cannot affect your mind or your mood. What it does is quietly support your body’s own balancing system.

07

Will I fail a drug test?

Our independent lab testing shows no detectable THC in these products, so the risk is very low. Even so, no product can promise a particular result on every test for every person.

If you are subject to regular or sensitive drug testing, check with your employer or testing provider first.

08

Is it THC-free? I didn’t see that on the label.

By law, hemp can carry a small legal trace of THC, under 0.3 percent, so products are not usually labelled THC-free. In this product, independent testing found THC to be non-detectable, below the level the lab can measure.

09

Is it just CBD?

No, and that is the point. This is not a single-ingredient CBD product. It brings together eleven different hemp compounds that work as a team. That teamwork, often called the entourage effect, is why a broad-spectrum blend gives more complete support than CBD alone.

10

How does it work?

Your endocannabinoid system has three working parts. First, your body makes its own messenger molecules, called endocannabinoids. Second, it has receptors, mainly CB1 (concentrated in the brain and nervous system) and CB2 (found more in the immune system, the skin and other tissues), that these messengers dock onto like a key fitting a lock. Third, it has enzymes that build the messengers when they are needed and clear them away once the job is done, so the system acts only when and where it should.

The hemp compounds in this are close natural relatives of your own endocannabinoids, so they fit the same receptors and work alongside the same enzymes. When your own supply is running low, they help top up the signal, giving the system a little more to work with as it does its everyday job of keeping the body in balance.

11

So it is not only for one thing?

That is right. The endocannabinoid system is not tied to a single job. It helps keep everyday things like comfort, the skin, rest and recovery in balance throughout the body, so supporting it can be useful in more than one situation rather than for a single, narrow purpose.

12

How fast does it work?

It depends on your own system. Some people notice a soothing effect within five to ten minutes. For others it takes longer, because the body works with it rather than masking a feeling. Give it a fair chance.

13

How often should I use it?

For steady support, many people use it through the day while they need it, then ease back to morning and night once things settle. Use it as often as feels comfortable.

14

Can I use the salve on everyday skin?

Yes. It is a gentle, soothing balm, so many people use it for everyday skin comfort, dryness and minor irritation. Apply a small amount and give it about ten minutes. As with any new skincare, try a small patch first.

15

Is it safe? Any side effects?

It is made from natural plant oils and hemp, and is generally well tolerated. As with any botanical product, do a small patch test first, and stop if it does not suit you. If you are pregnant, nursing or taking medication, check with your healthcare provider before use.

16

Is it vegan and natural?

The Kaneh Bosm Oil is fully plant-based (vegan), made only from natural botanical oils with no synthetic additives. The Salve is all-natural with no synthetic additives, but it contains natural beeswax, so it is not vegan.

What’s Inside

The Hemp Compounds

Built on a broad-spectrum hemp extract. Rather than one isolated compound, it carries a range of cannabinoids that each act on their own receptors and pathways. The notes below summarise what published research has observed for each molecule, with the stage of evidence and the source shown.

A note on the evidence. Most of what follows comes from laboratory and animal research rather than large human trials. That gap has less to do with the compounds than with their history. For decades cannabis sat under Schedule I restrictions that made human studies slow, costly and hard to supply, and hemp only returned to legal research in the United States with the 2018 Farm Bill. Because these are natural molecules that are difficult to patent, there has also been little commercial incentive to fund the large, expensive trials that carry a drug to market. The preclinical findings are consistent and encouraging, and human research is now beginning to catch up, but until it does these should be read as promising science rather than proven treatment.
CBD (Cannabidiol)Studied at more than sixty molecular targets. It is an agonist at the TRPV1 channel, PPAR-gamma and the 5-HT1A serotonin receptor, blocks GPR55, and inhibits the FAAH enzyme, which raises the body’s own anandamide. Through these routes preclinical research reports antioxidant and anti-inflammatory activity and modulation of nerve and immune signalling. [1]
CBG (Cannabigerol)Pharmacologically distinct from the rest: a potent alpha-2 adrenoceptor agonist and 5-HT1A antagonist, with only weak CB1 and CB2 activity. [2] In animal models it eases experimental colitis and inflammatory bowel disease through CB2, lowering nitric oxide and oxidative stress in the gut. [3] It also shows strong antibacterial activity in vitro, including against MRSA. [4]
CBN (Cannabinol)A mild, CB2-preferring cannabinoid formed as THC ages, with activity at TRPV1 and other TRP channels. In cultured human skin cells it engages the endocannabinoid system and shows anti-inflammatory effects. [11] It is also studied for sedation and appetite.
CBC (Cannabichromene)A potent TRPA1 agonist that also raises endocannabinoid tone by slowing anandamide reuptake. In human sebocytes it suppresses oil (sebum) production and inflammation, the basis for acne and seborrhoea research. [5] In pancreatic and lung cancer cell lines, and in mice, it has induced apoptosis and ferroptosis, forms of programmed cancer-cell death, via TRPV1 and CB2. [6] It is also anti-inflammatory in human keratinocytes. [11]
CBDV (Cannabidivarin)A propyl relative of CBD that acts mainly through TRP channels, activating TRPV1, TRPV2 and TRPA1 and desensitising TRPM8. [7] This underlies the anticonvulsant and neuroprotective activity seen in preclinical models, and it is anti-inflammatory in skin cells. [5]
CBDA (Cannabidiolic acid)The raw, unheated acid form of CBD, and a distinct molecule. It is a selective COX-2 inhibitor [8] and roughly one hundred times more potent than CBD at the 5-HT1A receptor, a key anti-nausea and anti-inflammatory pathway. [9] It also tends to be more bioavailable than CBD.
CBGA (Cannabigerolic acid)The parent acid the plant converts into the other cannabinoids. Preclinical work points to PPAR and TRP-channel activity, with early signals for metabolic and anticonvulsant effects.
CBE (Cannabielsoin)An oxidation product of CBD. Little studied in isolation; it contributes to the full-spectrum profile of the extract.
CBT (Cannabitriol)A rare, minor cannabinoid with limited pharmacology to date. Early reports note possible vasodilatory (blood-vessel widening) activity.
CBL (Cannabicyclol)A stable breakdown product of CBC. Data are limited, with preliminary anti-inflammatory and antibacterial signals in vitro.
THCV (Tetrahydrocannabivarin)A propyl cannabinoid that acts as a CB1 antagonist at low doses and a CB2 partial agonist. In animal models of obesity this improves insulin sensitivity and glucose handling and reduces fat accumulation. [10] It is also anti-inflammatory in human sebocytes. [5]

The effects above are drawn from preclinical and laboratory research (cell and animal studies) into the individual cannabinoids, and are provided for scientific education. They characterise the compounds, not this product, and have not been established as clinical effects in humans. Nothing here is intended to diagnose, treat, cure or prevent any disease.

Evidence

  1. de Almeida DL, Devi LA. Diversity of molecular targets and signaling pathways for cannabidiol. Pharmacology Research & Perspectives, 2020.
  2. Cannabigerol (CBG): a comprehensive review of its molecular mechanisms and therapeutic potential. 2024.
  3. Borrelli F, et al. Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochemical Pharmacology, 2013.
  4. Farha MA, et al. Uncovering the hidden antibiotic potential of cannabis: cannabigerol against MRSA. ACS Infectious Diseases, 2020.
  5. Oláh A, et al. Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions. Experimental Dermatology, 2016.
  6. Cannabichromene: integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy. Cell Death Discovery, 2025.
  7. Iannotti FA, et al. Nonpsychotropic plant cannabinoids CBDV and CBD modulate and desensitise TRP channels. ACS Chemical Neuroscience, 2014.
  8. Takeda S, et al. Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metabolism and Disposition, 2008.
  9. Bolognini D, et al. Cannabidiolic acid prevents vomiting via activation of 5-HT1A receptors. British Journal of Pharmacology, 2013.
  10. Wargent ET, et al. The cannabinoid THCV ameliorates insulin sensitivity in mouse models of obesity. Nutrition & Diabetes, 2013.
  11. Rare phytocannabinoids exert anti-inflammatory effects on human keratinocytes via the endocannabinoid system and MAPK signalling. 2023.
What’s Inside

The Natural Ingredients

Salve

A soothing natural balm for the skin. All-natural with no synthetic additives. Contains natural beeswax, so it is not vegan.

Whole-plant hemp blendThe active heart of the balm: the broad spectrum of hemp compounds described above, chosen to support the endocannabinoid system where you apply it.
BeeswaxForms a breathable protective layer that seals in moisture and shields the skin. It also gives the balm its structure, so the actives stay where you place them.
Coconut oilA rich emollient that softens and smooths the skin, helps the balm glide on, and carries the hemp compounds in.
Hemp seed oilRich in skin-loving omega fatty acids that nourish and condition the skin and support its moisture barrier. These are the same building blocks the body uses.
Sacha inchi oilOne of the richest plant sources of omega-3, adding a softening, barrier-supporting boost.
Beta-caryophylleneA natural plant terpene, also found in black pepper and cloves, that is unusual in acting directly on the body’s CB2 endocannabinoid receptors. It is included to reinforce the formula’s ECS support.

Kaneh Bosm Oil

A blend of botanical oils. Fully plant-based (vegan), all-natural, with no synthetic additives.

Whole-plant hemp blendThe active heart of the formula: the broad spectrum of hemp compounds described above, chosen to support the endocannabinoid system.
Hemp seed oilRich in balanced omega-3 and omega-6 fatty acids that nourish the skin and support its natural moisture barrier, and that carry the hemp compounds. These are the same building blocks the body uses.
Black seed oilNigella sativa oil, naturally high in the antioxidant thymoquinone along with vitamin E. Chosen to help condition and calm the skin and support its lipid barrier.
Sacha inchi oilOne of the richest plant sources of omega-3. It helps strengthen the skin’s moisture barrier and keep it soft and supple.
Jojoba oilA liquid wax that closely matches the skin’s own oils, so it absorbs cleanly, helps balance moisture and reduce water loss, and carries the other oils deeper into the skin.
Olive oilRich in squalene, a natural part of the skin’s own oils, and in antioxidant polyphenols. A nourishing base that softens skin and helps defend it against everyday oxidative stress.
FrankincenseBoswellia resin, chosen for its natural toning, astringent quality that helps balance oil and refine the look and feel of the skin, and for its calming, grounding aroma.

Important. These statements have not been evaluated by the Food and Drug Administration. These products describe how they support the body’s own systems and are not intended to diagnose, treat, cure or prevent any disease.

This guide is for general education only and is not a substitute for professional medical advice. If you are pregnant, nursing, taking medication, or have a medical condition, consult your healthcare provider before use.